•The limit of detection (LOD) is the
conc. at which one is 95% confident the analyte is present in
the
•sample.
The LOD is affected by the precision of the measurements and by the magnitude of
the blanks.
•From
multiple measurements of blanks, determine the standard deviation of the
blank signal
sbl
•Then
LOD = 3sbl /m where m is the
sensitivity.