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Chemistry
121, Winter 2008, LA Tech
Organic acids
Higher the pKa higher
the acidity
The most important factor in determining the relative
acidity of an organic acid is the relative stability of
the anion, A-, formed when the acid, HA, transfers a proton to a base
There are three factors:
•the electronegativity of the atom
bonded to H in HA
•resonance stabilization of A-
•the inductive effect
Molecular Structure and acidity